6 resultados para Attention deficit, hyperactivity disorder, adrenergic receptor

em Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco


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[eus] Arreta Faltaren Nahastea eta Hiperaktibitatea (AFNHa) gaur egun ikasgela batean aurki dezakegun nahaste ohikoenetariko bat da. Nahastea pairatzen duten umeek haien errendimendu akademikoan negatiboki eragiten duten zailtasun desberdinei aurre egin behar diete. Irakasleen ezagutza edo parte-hartze eza dela eta, ume horiei arrakasta lortzeko ez zaie beti bere esku jartzen gainontzekoei eskaintzen zaizkien aukera berdinak. Hortaz, irakasleak laguntzea eta ume horiei ikasgela baten barruan ahalik eta erantzun egokien ematea ikerketa lan honen helburua da. Horretarako, bilaketa bibliografiko baten bitartez, nahastean sakondu da eta estrategia desberdinak, metodologia egokia eta IKTen (Informazioaren eta komunikazioaren teknologien) erabilera proposatu dira. Inor atzean utzi gabe, guztientzako kalitatezko eta inklusiboa den hezkuntza defendatzen duen eta itxaropenerako bidea irekitzen saiatzen den lana da.

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[EN] Panic disorder is a highly prevalent neuropsychiatric disorder that shows co-occurrence with substance abuse. Here, we demonstrate that TrkC, the high-affinity receptor for neurotrophin-3, is a key molecule involved in panic disorder and opiate dependence, using a transgenic mouse model (TgNTRK3). Constitutive TrkC overexpression in TgNTRK3 mice dramatically alters spontaneous firing rates of locus coeruleus (LC) neurons and the response of the noradrenergic system to chronic opiate exposure, possibly related to the altered regulation of neurotrophic peptides observed. Notably, TgNTRK3 LC neurons showed an increased firing rate in saline-treated conditions and profound abnormalities in their response to met5-enkephalin. Behaviorally, chronic morphine administration induced a significantly increased withdrawal syndrome in TgNTRK3 mice. In conclusion, we show here that the NT-3/TrkC system is an important regulator of neuronal firing in LC and could contribute to the adaptations of the noradrenergic system in response to chronic opiate exposure. Moreover, our results indicate that TrkC is involved in the molecular and cellular changes in noradrenergic neurons underlying both panic attacks and opiate dependence and support a functional endogenous opioid deficit in panic disorder patients.

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Póster presentado en The Energy and Materials Research Conference - EMR2015 celebrado en Madrid (España) entre el 25-27 de febrero de 2015